Table 1.
Diagnostic, histological, and physiological markers of severity in the different experimental groups
| Test | Saline control | Caerulein-induced mild pancreatitis | Sham surgery | Taurocholate-induced severe pancreatitis |
|---|---|---|---|---|
| Histological score1 | 1.0 ± 0.2a | 4.8 ± 0.5a,c | 0.7 ± 0.2b | 8.9 ± 0.3b,c |
| Amylase(U/l) | 1489 ± 152a | 5990 ± 458a,c | 1409 ± 150b | 12 848 ± 1 909b,c |
| Sodium(mmol/l) | 132.8 ± 1.4 | 137.0 ± 2.1 | 136.9 ± 1.3 | 130.0 ± 1.7 |
| Potassium(mmol/l) | 4.7 ± 0.2 | 4.6 ± 0.2 | 4.7 ± 0.1 | 5.2 ± 0.3 |
| Chloride(mmol/l) | 95.9 ± 1.2 | 99.0 ± 1.3 | 97.4 ± 1.9 | 91.0 ± 2.3 |
| Glucose(mmol/l) | 11.0 ± 0.9 | 11.2 ± 1.3 | 10.2 ± 1.2 | 14.3 ± 1.8 |
| Urea | 5.8 ± 0.2 | 6.3 ± 0.1 | 7.4 ± 1.2b | 13.3 ± 1.2b |
| Creatinine(µmol/l) | 31.8 ± 1.4 | 35.5 ± 1.3 | 36.3 ± 2.5b | 81.0 ± 14.4b |
| Calcium(mmol/l) | 2.52 ± 0.04 | 2.53 ± 0.03 | 2.56 ± 0.05 | 2.61 ± 0.05 |
| Albumin(g/l) | 34.6 ± 0.9 | 35.2 ± 0.8 | 35.4 ± 0.5 | 33.6 ± 0.8 |
| Bilirubin(µmol/l | <2 | 2 | <2 | 18.9 ± 9.4 |
| GGT(U/l) | <2 | <2 | <2 | 16 ± 2 |
| ALP(U/l) | 84 ± 7 | 72 ± 14 | 63 ± 3b | 105 ± 11b |
| AST(U/l) | 83 ± 12 | 72 ± 21 | 108 ± 4 | 5437 ± 2303 |
| ALT(U/l) | 50 ± 4 | 44 ± 15 | 56 ± 9b | 739 ± 328b |
Values are mean ± SEM;
1
Histology score is for pancreatic tissue. Values for bilirubin <2 and GGT < 2 were below the limit of detection and not quantified further by the Roche/Hitachi MODULAR® analytical system. Like-letters indicate P < 0.05 for the Mann–Whitney U-tests with Bonferroni's correction.