Table 5.

Sensitivity, Specificity, Likelihood Ratios, and Predictive Values of FibroScan Measurements for Predicting Fibrosis in All Etiologies of Liver Disease

Fibrosis	FibroScan (kPa)	Sensitivity (%)	Specificity (%)	LR+	LR−	PPV (%)	NPV (%)
Gold standard: Histology only
Stage 4	11.8*	85	82.7	4.92	0.18	55	95.7
	18.4	60	94	9.72	0.43	70.6	90.5
	20.9	50	96.3	13.5	0.52	76.9	88.6
Stage ≥3	7.6	86.7	67.9	2.7	0.2	68.4	86.4
	9.5*	73.3	82.1	4.11	0.32	76.7	79.3
	11.9	57.8	94.6	10.79	0.45	89.7	73.6
Stage ≥2	7*	71.4	79	3.43	0.36	92	46.3
	8.7	58.4	91.7	7.01	0.45	95.7	40.7
Stage ≥1	5.3	88.5	57	2.07	0.2	93	44.4
	7	66.7	85.7	4.67	0.39	96.7	29.3
Gold standard: Gross nodularity on laparoscopy only
Cirrhosis	11.8	76.5	78.6	3.57	0.3	41.9	94.3
	14	70.6	85.7	4.94	0.34	50	93.5
	20.4*	64.7	95.2	13.59	0.37	73.3	93
Gold standard: Histology and/or gross nodularity
Cirrhosis	11.8*	80	85.5	5.53	0.23	64.5	92.9
	14.3	60	89.5	5.7	0.45	65.2	87.2
	18.4	56	96	14.2	0.46	82.4	87

Sensitivity, specificity, likelihood ratios, and predictive values of FibroScan measurements for all patients (N=101) based upon various gold standards (histology and/or gross nodularity).

^*Highest accuracy.

LR+

positive likelihood ratio

LR–

negative likelihood ratio

NPV

negative predictive value

PPV

positive predictive value.

For prevalence of fibrosis and cirrhosis, see Tables 2 and 4.