. 2008 May;4(5):337–347.

Table 8.

Ciprofloxacin Drug Interactions

Drug	Cytochrome Association	↑ Levels/Effects of CYP1A2 Substtates	Dtug-Dtug Intetaction	Renal Impaitment
Ciprofloxacin	Inhibits CYP: 1A2 (strong) 3A4 (weak)	aminophylline fluvoxamine mexiletine mirtazapine ropinirole tizanidine trifluoperazine	Caffeine: may decrease caffeine metabolism Foscatnet: associated with an increased risk of seizures Glybutide: may increase therapeutic effects Methottexate: may decrease renal secretion NSAIDs: risk of seizures may be increased Phenytoin: may decrease levels Ptobenecid: concurrent usage may decrease renal excretion Sevelamet: may decrease oral absorption Theophylline: levels may increase Tizanidine: levels may increase—contraindicated Watfatin: anticoagulant effect may be enhanced Metal cautions (aluminum, calcium, iton, magnesium, and zinc): bind quinolones in the gastrointestinal tract and inhibit absorption	Caution warranted with renal impairment —dosage adjustment required