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. Author manuscript; available in PMC: 2011 May 13.
Published in final edited form as: Curr Top Microbiol Immunol. 2009;339:125–146. doi: 10.1007/978-3-642-02175-6_7

Figure 2. Structure of NUP 98-LEDGF/p75 fusion proteins.

Figure 2

NUP98 contains eight N- terminal GLFG repeats that govern localization of the protein to nuclear GLFG bodies. GLEBS is a sequence within the GLFG repeats that serves as docking site to GLE2p, the yeast ortholog of human RAE1 a protein involved in mRNA nuclear export. Nucleoporin RNA binding motif (NRM) is an octapeptide with partial homology to the ribonucleoprotein motif. In the NUP98-LEDGF/p75 fusion proteins (I–III) described in leukemic patients, the NUP98 GLFG repeats and the GLEBS element fuse to LEDGF/p75 segments that contain the IBD.