Table 1.
Gene-to-protein relationship in LEDGF proteins
| Exon | Amino acids | Protein domain | p75 mRNA segment |
|---|---|---|---|
| 1 | 1–23 | PWWP | 1–382 |
| 2 | 24–50 | PWWP | 383–459 |
| 3 | 51–96 | PWWP, CR1 | 460–598 |
| 4 | 97–131 | CR1 | 599–703 |
| 5 | 136–152 | CR1, NLS | 704–766 |
| 6 | 153–184 | NLS, AT | 767–863 |
| 7 | 185–210 | AT, CR2 | 864–939 |
| 8 | 211–286 | CR2, CR3 | 940–1168 |
| 9 | 287–326 | CR3 | 1169–1287 |
| 10 | 327–344 | 1288–1343 | |
| 11 | 345–368 | IBD | 1344–1414 |
| 12 | 369–402 | IBD | 1415–1516 |
| 13 | 403–472 | IBD | 1517–1731 |
| 14 | 473–511 | 1732–1843 | |
| 15 | 512–530 | 1844-poly(A) signal | |
| 9-A | *287–326 | CR3 | |
| 10-A | *327–333 | C-terminal region |
*
Exons 9-A and 10-A encode CR3 and the C-terminal region of LEDGF/p52. Exon 9 and exon 9-A have identical nucleotide sequences, except different terminal amino acids are encoded (Q for 9, and H for 9-A)