FIGURE 9.

MGL-ko mice receiving a high fat diet exhibit improved insulin sensitivity and glucose tolerance. For insulin and glucose tolerance tests (ITT and GTT), male mice were fasted for 4 and 6 h, respectively. Mice received an intraperitoneal injection of 0.75 IU of insulin or 1.5 mg of glucose per kg of body weight. Insets show the area under the curve (AUC). a, ITT and GTT were performed with male mice at the age of 12 weeks receiving a normal chow diet (n = 6 per genotype). b, ITT and GTT were performed with mice set on a high fat diet for 12 weeks (n = 10 for each genotype). Data are presented as mean ± S.D. *, p < 0.05; **, p < 0.01.