FIGURE 6.

Peroxynitrite inhibited KGDHC activity in N2a cells. N2a cells were treated with different concentrations of peroxynitrite (0, 0.0625, 0.125, 0.25, 0.5, and 1 mm) for 5 min and allowed to recover in normal medium for 24 h. Then cells were harvested, and the KGDHC activity was measured in cell lysates. Values are means ± S.E. of at least two independent experiments done in triplicate. Values with different letters are significantly different from each other (p < 0.05) as determined by a one-way ANOVA followed by a Student-Newman-Keul's test.