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. 2011 Mar 28;286(20):17821–17830. doi: 10.1074/jbc.M111.228791

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 2. — MKK4-regulated Cx43 transcription is dependent on AP-1 transcriptional activity. A, schematic diagram of mutated rCx43 promoter-luciferase constructs (mutated nucleotides are underlined and in boldface). B, the infection of Ad-caMKK4 significantly increased the AdCx43APwt-Luc activity. *, p < 0.01 versus Ad-GFP + Ad-Cx43APwt-Luc. Ad-Cx43APdm-Luc activity was decreased even at the basal level. †, p < 0.05 compared with Ad-GFP + Ad-Cx43APwt-Luc. Co-infection of Ad-caMKK4 and Ad-Cx43APdm-Luc could not ameliorate the reduction. ##, p < 0.001 versus Ad-caMKK4 + Ad-Cx43APwt-Luc. Moreover, co-infection of Ad-caMKK4 failed to restore the reduced luciferase level induced by Ad-Cx43APma-Luc or Ad-Cx43APmb-Luc. #, p < 0.01 versus Ad-caMKK4 + Ad-Cx43APwt-Luc (n = 6 per group). Data are mean ± S.E.