TABLE 1.
Electrocardiographic assessment of MKK4f/f and MKK4cko mice one week after TAC
P-wave duration, QRS complex duration, and intervals of RR, PR, JT, and QT were recorded from anesthetized mice. QTc was obtained by correction for the heart rate. Data are presented as mean ± S.E. *, p < 0.01 versus MKK4f/f-TAC mice.
| ECG parameters | Sham |
TAC |
||
|---|---|---|---|---|
| MKK4f/f (n = 7) | MKK4cko (n = 6) | MKK4f/f (n = 11) | MKK4cko (n = 13) | |
| Heart rate (bpm) | 376 ± 12 | 403 ± 13 | 391 ± 17 | 398 ± 15 |
| P duration (ms) | 10.2 ± 0.9 | 10.1 ± 1.0 | 11.3 ± 1.1 | 10.5 ± 0.7 |
| RR interval (ms) | 161.36 ± 6.1 | 150.15 ± 5.4 | 157.00 ± 6.07 | 158.20 ± 10.15 |
| PR interval (ms) | 39.99 ± 1.90 | 38.38 ± 1.70 | 37.92 ± 1.99 | 37.36 ± 2.28 |
| QRS duration (ms) | 10.27 ± 0.75 | 10.50 ± 0.51 | 10.37 ± 0.46 | 16.02 ± 0.62* |
| QTc (ms) | 69.47 ± 4.34 | 76.59 ± 3.30 | 69.95 ± 3.64 | 90.69 ± 2.54* |
| JT (ms) | 17.63 ± 1.28 | 19.10 ± 1.60 | 17.19 ± 1.33 | 19.44 ± 0.71 |
| QRS/QTc | 0.15 | 0.14 | 0.15 | 0.18* |