FIGURE 2.

A, stimulation of rat liver mitochondria respiration by SkQR1. Shown are traces of the rate of respiration in the medium described under “Materials and Methods.” Additions were as follows: 5 mm succinate, 2 μm rotenone, 2 μm SkQR1, 2 μm SkQR4, 1 μm FCCP (trace with SkQR1), and two additions of FCCP (0.5 μm) in the trace with SkQR4. B, dose dependence of respiratory stimulation by SkQR1, SkQR4, C₁₂R1, C₁₂R4, and FCCP. C, the increase in the respiration rate caused by C₁₂R1 was insensitive to the addition of carboxyatractilate (2 μm). Error bars, S.E.