FIGURE 11.

A cooperative action of annexins A1 and A6 in plasmalemmal repair. A, the scheme depicts the repair of a single SLO pore (steps 2 and 2a) or that of three SLO pores assembled simultaneously (steps 3 and 3a). B, the scheme depicts the repair of a single SLO pore assembled within the plasmalemma of the cell body (step 2) or that of two pores assembled within the plasmalemma of a thin cellular protrusion (steps 3–5). Two annexins, which differ in their Ca²⁺ sensitivity of plasmalemmal association, are shown by blue crosses (the annexin with a higher Ca²⁺ sensitivity, annexin A6) and orange circles (the annexin with a lower Ca²⁺-sensitivity, annexin A1). The green lines depict spatiotemporal variations in [Ca²⁺]_i corresponding to each step. Ca²⁺-sequestrating organelles (endoplasmic reticulum, mitochondria, not shown) are preferentially localized in the perinuclear region (n = nucleus).