FIGURE 1.

Schematic representation of domain organization and different constructs of p115, p190, PRG, and LARG used in this study. The numbers indicate the N- and C-terminal amino acids of the respective constructs. DH-PHn, DH-PHc, and DH-PHcn are shorter variants at the N and C termini of p115 DH-PH that are equivalent to LARG DH-PH (see supplemental Fig. S2A). DH-PHcnΔN and DH-PHΔN are N-terminally deleted variants of p115 and LARG and equivalent to each other. DH-PHΔN2m contains two point mutations at positions Asn⁹⁴⁶ and Lys⁹⁴⁹ that are substituted by Ser and Gln, the corresponding residues in p115. C1, cysteine-rich region; cc, coiled coil; L, leucine-rich; P, proline-rich.