Table 3.
Partial list of overexpressed proteins that were previously reported in esophageal squamous cell carcinoma
| Gene symbol | Protein | Features | Citation | Fold change upregulation in this study | ||
| Spectrum mill | Mascot distiller | |||||
| 1. | HSPA1A | Heat shock 70 KD protein 1A | HSP72 overexpression was observed in ESCC tumors with low differentiation. It is known to be involved in oncogenic transformation of epithelial carcinomas. | Hoshino et al. (2007)90 | 19.3 | Not detected in Normal |
| 2. | CALR | Calreticulin | Endoplasmic reticulum protein reported to be overexpressed in 66% of ESCC cases. | Du et al. (2007)20 | 6.9 | 3.4 |
| 3. | MMP13 | Matrix metallopeptidase 13 (collagenase) | MMP13 upregulation and overexpression has been reported earlier in ESCC. It is an independent and negative indicator of prognosis for ESCC. | Gu et al. (2005);91 Kashyap et al. (2009)41 | Not detectable in normal | 14.2 |
| 4. | LCN2 | Lipocalin 2 | Extracellular protein involved in cell-cell adhesion. | Zhang et al. (2007)50 | Not detectable in normal | 2.9 |
| 5. | TFRC | Transferrin receptor | Transmembrane protein involved in iron transport and cellular homeostastsis. Reported as prognostic marker for distant metastasis in ESCC. | Wada et al. (2006)42 | 4.3 | 3.6 |
| 6. | TGFBI | Transforming growth factor beta induced 68 kda | Extracellular protein involved in signal transduction. Reported to be a marker for tumor metastasis in ESCC patients. | Wong et al. (2009)72 | 9.4 | 6.1 |
| 7. | VCP | Valosin-containing protein | ATP binding protein involved in vesicular transport. Reported as prognostic marker for disease free survival in ESCC patients. | Yamamoto et al. (2004)92 | 6.7 | 3.4 |
| 8. | MMP1 | Matrix metallopeptidase 13 or collagenase | It is an interstitial collagenase. MMP1 upregulation and overexpression was observed in ESCC. | Kashyap et al. (2009)41 | 23.8 | 7.7 |
| 9. | THBS1 | Thrombospondin 1 | Extracellular matrix protein involved in cellcell adhesion. Reported to be upregulated in ESCC. | Kashyap et al. (2009)41 | 2.3 | 5.3 |
| 10. | HSP90AA1 | Heat shock protein 90 kDa alpha (cytosolic), class A member 1 | HSP90 overexpression has been reported in esophageal cancers and the preclinical studies and its report in different biological fluids make indicates HSP90 as a promising therapeutic target for ESCC. | Wu et al. (2009)93 | 3.9 | - |