Table 4.
Partial list of novel proteins identified as overexpressed in esophageal squamous cell carcinoma
| S. no. | Gene symbol | Protein | Features | Fold upregulation | |
| Spectrum mill | Mascot | ||||
| 1. | GDI2 | GDP dissociation inhibitor 2 | An ECM protein with one signal peptide, is involved in vesicular trafficking between cellular organelles. Significant overexpression of GDI2 was found in pancreatic adenocarcinoma cases. | 3.6 | 2.5 |
| 2. | IGFBP7 | Insulin like growth factor binding protein 7 | Extracellular glycoprotein involved in signal transduction. Reported as potential biomarker in gastric cancer | 3.6 | 12.2 |
| 3. | PLEC1 | Plectin 1 intermediate filament binding protein 500 kda | Cytoskeletal protein involved in cytoskeletal-membrane attachment in epithelial cells, muscle and other tissues. Potential biomarker for diagnosis of Pancreatic ductal adenocarcinoma | Not detectable in normal | 12.8 |
| 4. | SERPINC1 | Antithrombin III | An extracellular matrix serine (or cysteine) proteinase inhibitor. It's overexpression has been reported in chronic pancreatitis as compared to normal pancreas. | 10.3 | 3.9 |
| 5. | CCT6A | Chaperonin containing T complex subunit 6 | Cytoplasmic protein with chaperone activity. Overexpression of TCP1 shown to be associated with radioresistance in oral squamous cell carcinoma | 2.5 | - |
| 6. | SPTAN1 | Spectrin alpha non erythrocytic 1alpha fodrin | Cytoskeletal protein involved in cell growth. Shown to be associated with chemoresistance in colorectal cancer | 2.5 | - |
| 7. | KPNB1 | Importin beta1 | Cytoplasmic protein with transporter activity. Reported to be overexpressed in cervical cancer | 2.2 | 6.3 |
| 8. | TIAM1 | T-cell lymphoma invasion and metastasis 1 | It is cytoplasmic and secreted protein with one PDZ domain. It's significantly overexpressed in prostate cancer. | 25.7 | - |
| 9. | LGALS3BP | Mac 2 binding protein | LGALS3BP is a secreted protein involved in involved in cell-cell and cell-matrix interactions and reported as overexpressed in prostate and thyroid cancers. | 9.3 | 9.0 |
| 10. | PIWIL2 | Cancer testis antigen 80 | Piwi like 2 drosophila overexpression has been reported in gastric adenocarcinoma. | 4.4 | - |