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. Author manuscript; available in PMC: 2011 May 13.
Published in final edited form as: Int J Radiat Biol. 2010 Mar;86(3):220–229. doi: 10.3109/09553000903419338

Figure 1.

Figure 1

In vitro cytotoxicity of CRAd in combination with two types of radiation. LNCaP cells were infected with 2 MOI of Ad5 PSE/PBN E1A-AR on 48-well plates for both combinations. In (a), acute single HDR radiation (6 Gy) was performed 24 hours prior to infection. In (b), continuous LDR radiation (6 Gy) was performed immediately after infection. MTT assay was used to assess cell viability. The enhanced cytotoxicity of the CRAd monotherapy in the LDR experiment, in comparison to the HDR experiment, is due to the difference in shorter time gap (24 hours vs. 48 hours) between cell plating and viral infection. Error bars indicate the standard error of the mean (SEM) for three independent experiments.