Fig. 11.

Ryr1^D/D mice exhibit decreased twitch force generation and increased force summation in vivo. A: representative twitch (single AP) and tetanic (100 Hz, 200 ms) force responses from the tibialis anterior muscles of anesthetized Ryr1^+/+ and Ryr1^D/D mice. B: force vs. frequency of stimulation relationships for Ryr1^+/+ (n = 5) and Ryr1^D/D (n = 6) mice. C: specific twitch force of Ryr1^+/+ and Ryr1^D/D mice. D: specific tetanic force of Ryr1^+/+ and Ryr1^D/D mice. E: tetanus-to-twitch ratio, an indicator of summation, of Ryr1^+/+ and Ryr1^D/D mice. *P < 0.05