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CaM regulation of RyR1 from skeletal muscle of Ryr1+/+ and Ryr1D/D mice. Specific [3H]ryanodine binding to crude membrane fractions from skeletal muscle of Ryr1+/+ (•) and Ryr1D/D (○) mice was determined at the indicated CaM concentrations in the presence of 0.15 μM Ca2+ and 1 mM AMPPCP (a nonhydrolyzable ATP analog) (A) and 25 μM (B) free Ca2+ as described in experimental procedures. Data are means ± SE of 4 experiments. *P < 0.05 compared with control (−CaM).
