Fig. 7.
Outflow facility effects of S1P2 receptor blockade in S1P-perfused human eyes. Following a baseline perfusion in paired human eyes, the contents of the anterior chambers of the experimental eyes were exchanged with media containing 5 μM JTE-013 + 5 μM S1P, while the contralateral S1P control eyes received 5 μM S1P alone. Examples of outflow facility traces for experiments comparing S1P control (−) to JTE-013 + S1P experimental (. . . .) eyes are shown (A); paired eyes were from an 85 yr-old donor (87C, 88E) with a net facility increase of 23.8% with the inclusion of JTE-013, compared with S1P control. Average normalized facilities following anterior chamber exchanges are shown (B). Data are presented as means ± SD (*P < 0.05).