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Increased mRNA expression in the TgPWS pancreas of genes encoding hormones and cosecreted products (A–E), polypeptides involved in secretion (F and G), and a transcriptional regulator (H). Steady-state mRNA levels were assessed by quantitative RT-PCR using total RNA from pancreata of 4 TgPWS and 4 control mice at P1 and normalized to Gapdh mRNA levels. Results are mean fold change ± SE. *P < 0.05, significant differences between TgPWS and WT mice (independent t-test).
