Fig. 1.
A: average glycemic control measured in streptozotocin-induced diabetes mellitus (Stz-DM) and control monkeys as %glycosylation of Hb A1c. Open bars, control monkeys (n = 5 at baseline); hatched bars, moderately controlled hyperglycemic monkeys (n = 4); black bars, poorly controlled hyperglycemic monkeys (n = 5). *After baseline, all diabetic animals were significantly higher than control; #from weeks 8 through 16, the poor control group had significantly higher Hb A1c values than moderate control. At 20 wk, only 2 monkeys were evaluated. Duration of diabetes correlated with Hb A1c (r = 0.82, P < 0.001). B: postprandial glucose concentrations measured in whole blood from Stz-DM and control monkeys. Postprandial glucose was measured twice weekly to adjust insulin doses to achieve a postprandial glucose value of <150 mg/dl in the moderate control group (▴ with dotted line) or between 250 and 350 mg/dl in the poor control group (● with solid line). ○, Control animals.