Fig. 3.

Primary increase in proximal tubular reabsorption and strong suppression by high NaCl intake in the early diabetic kidney. Absolute proximal fluid reabsorption is shown as a function of single nephron GFR. Single nephron GFR was manipulated by perfusing Henle's loop downstream of an obstructing wax block and activating TGF to characterize reabsorption up to the late proximal tubule at similar levels of single nephron GFR in control rats (CON) and diabetic rats (STZ) on normal vs. high-NaCl diet. *P < 0.05 comparing the influence of STZ or high NaCl. [Modified from (150).]