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2ME2 treatment in cpk mice. Cpk mice were treated with the HIF-1α inhibitor 2ME2 or vehicle from 14 to 21 days of age. Kidneys were removed at death for determination of HIF-1α protein, kidney size as determined by 2K/TBW ratio, and CVD. 2ME2 treatment (2 mg·kg−1·day−1 ip) resulted in inhibition of HIF-1α as determined by immunoblotting. There was no significant difference in 2K/TBW ratio and CVD between vehicle- and 2ME2-treated cpk mice; n = 3/group.
