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p38 MAPK is activated by CP/R. A: immunoblot analysis of isolated heart LV tissue probed with anti-phospho-p38 MAPK and total p38 MAPK. B: normalized fold increase in phosphorylation over sham. Values are means ± SE; n = minimum of 6 per group. *P < .05 vs. sham (1-way ANOVA, Holm-Sidak). S, sham; CP, 2 h of cardioplegia + 30 min of reperfusion; CP +SB, 2 h of cardioplegia with 5 μM SB-203580 + 30 min of reperfusion.
