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. 2011 Mar 4;300(5):H1822–H1828. doi: 10.1152/ajpheart.00766.2010

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Fig. 1. — Spontaneous diastolic calcium oscillations were induced by 15 s of rapid pacing followed by a pause. Shown in each panel are the electrocardiogram (ECG, top) and intracellular calcium (bottom) recorded from a single site on the epicardium under control conditions (A), control at a faster pacing rate (B), and with ryanodine (C). Under control conditions at 210 beats/min (A), a spontaneous diastolic calcium oscillation was observed (arrow) after termination of rapid pacing. S1, rapid pacing. A more rapid heart rate [330 beats/min (bpm)] resulted in a triggered beat (TA, B) with multiple oscillations of diastolic calcium (arrows). Ryanodine (1 μM, C) abolished TA and any spontaneous calcium oscillations during diastole.