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A: representative calcium traces with caffeine (CAFF) and without (control) upon the termination of rapid pacing (330 beats/min). Increasing ryanodine receptor (RyR) open probability (Po) with CAFF increases m-SCR amplitude (Amp) and decreases Tp. Summary data show that, over all experiments, CAFF increases m-SCR amplitude (B) and decreases Tp (C).
