Table 2.
Cytokine/chemokine levels in 6T/ApoE−/− mice compared with ApoE−/− mice
| NC |
WD |
|||||
|---|---|---|---|---|---|---|
| Protein Name | 6T/ApoE−/− mice | ApoE−/− mice | P value | 6T/ApoE−/− mice | ApoE−/− mice | P value |
| Total plasminogen activator inhibitor-1 | 3,094 ± 1,597 | 2,853 ± 1,077 | 0.70 | 6,348 ± 2,196 | 5,532 ± 656 | 0.44 |
| Vascular cell adhesion molecule | 1,092,000 ± 186,700 | 1,184,000 ± 179,800 | 0.29 | 1,015,000 ± 455,000 | 1,096,000 ± 559,800 | 0.77 |
| Intercellular cell adhesion molecule | 35,990 ± 10,620 | 36,680 ± 5,407 | 0.86 | 50,600 ± 19,790 | 56,490 ± 18,240 | 0.58 |
| Matrix metalloproteinase-9 | ND | ND | 14,590 ± 4,160 | 14,880 ± 9,070 | 0.94 | |
| Soluble E-selectin | 55,420 ± 50,440 | 46,380 ± 19,930 | 0.63 | 70,050 ± 16,530 | 48,920 ± 24,390 | 0.08 |
| Eotaxin [chemokine (C-C motif) ligand 11] | 336.1 ± 264.6 | 535.6 ± 122.4 | 0.046 | 408.2 ± 86.4 | 508.7 ± 94.99 | 0.06 |
| Granulocyte colony-stimulating factor | 317.4 ± 194.4 | 218.2 ± 84.9 | 0.16 | 519.4 ± 216.8 | 580.5 ± 278.1 | 0.65 |
| Interleukin-1a | 9.3 ± 0.8 | 34.9 ± 36.4 | 0.29 | 31.8 ± 25.2 | 26.5 ± 4.8 | 0.62 |
| Interleukin-6 | 17.5 ± 7.8 | 19.5 ± 8.5 | 0.78 | 88.0 ± 135.7 | 44.5 ± 50.3 | 0.62 |
| Interleukin-7 | 198.8 ± 221.3 | 21.3 ± 15.5 | 0.11 | 41.8 ± 28.6 | 198.1 ± 319.8 | 0.29 |
| Interleukin-12 p40 | 25.08 ± 9.01 | 47.94 ± 55.78 | 0.41 | ND | ND | |
| Interleukin-12 p70 | 215.7 ± 329.3 | 60.0 ± 68.5 | 0.42 | ND | ND | |
| Interleukin-15 | 2245 ± 4259 | 302 ± 190 | 0.22 | 431 ± 634 | 281 ± 168 | 0.62 |
| Interleukin-13 | 262 ± 127 | 468 ± 429 | 0.28 | 348 ± 227 | 339 ± 94 | 0.94 |
| Interferon-γ-induced protein, 10 kDa | 98.4 ± 106.1 | 72.3 ± 21.3 | 0.46 | 133.2 ± 65.3 | 152.6 ± 137.7 | 0.73 |
| Chemokine (C-X-C motif) ligand 1 (KC) | 21.07 ± 15.05 | 15.39 ± 8.80 | 0.47 | 74.41 ± 32.57 | 24.9 ± 18.41 | 0.01 |
| Chemokine (C-X-C motif) ligand 5 | 1708 ± 1250 | 2453 ± 1585 | 0.27 | 982 ± 1388 | 1159 ± 1129 | 0.80 |
| Monocyte chemoattractant protein-1 | 22.48 ± 20.03 | 32.94 ± 45.97 | 0.72 | 19.70 ± 12.60 | 7.62 ± 3.79 | 0.15 |
| Mitogen-inducible gene | 150.2 ± 88.7 | 112.2 ± 81.4 | 0.41 | 221.4 ± 101.6 | 156.7 ± 100.1 | 0.29 |
| Interleukin-4 | 4.42 ± 10.69 | 2.72 ± 3.37 | 0.64 | 0.92 ± 0.22 | 1.35 ± 1.19 | 0.41 |
| Interleukin-5 | 49.4 ± 76.9 | 6.2 ± 9.4 | 0.12 | 26.3 ± 35.1 | 8.1 ± 6.5 | 0.24 |
| Macrophage inflammatory protein-1a | ND | ND | 227.4 ± 345.5 | 166.7 ± 223.3 | 0.77 | |
| RANTES [chemokine (C-C motif) ligand 5] | 5.4 ± 3.9 | 12.1 ± 10.8 | 0.10 | 28.1 ± 63.9 | 15.2 ± 7.7 | 0.63 |
| Tumor necrosis factor-α | 24.0 ± 39.2 | 11.2 ± 10.8 | 0.50 | 6.1 ± 9.3 | 5.2 ± 2.4 | 0.87 |
| Vascular endothelial growth factor | 1.75 ± 0.74 | 1.95 ± 1.11 | 0.66 | 7.04 ± 14.03 | 1.42 ± 1.06 | 0.35 |
Values are means ± SE (in pg/ml). RANTES, regulated upon activation, normal T cell expressed, and secreted; ND, not detectable.