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Schematic showing effects of CARE-binding miRNAs and hnRNP L on VEGFA expression. In normoxia, translation of VEGFA mRNA is negatively regulated by endogenous miRNA/RISC complexes binding to CARE (left). In hypoxia, hnRNP L is translocated to cytoplasm where it binds CARE, prevents miRNA/RISC activity, and increases VEGFA expression (right).
