Table 2.

Metabolic parameters after a mixed meal by delivery route before and after gastric bypass surgery

	Gastric Route			Jejunal Route
	Preop	1st week	6 wk	1st week	6 wk	P Values
Glucose AUC, mg•l−1•min−1	3,317 ± 953	2,827 ± 418	3,012 ± 657	3,087 ± 1022	2,827 ± 737	T < .0001
						R 0.909
						R × T 0.084
Peak glucose, mg/dl	153 ± 38	132 ± 25	143 ± 26	144 ± 46	139 ± 36	T 0.070
						R 0.852
						R × T 0.444
Insulin AUC, μU•l−1•min−1	19.0 ± 11.1	13.0 ± 5.5	11.7 ± 7.4	10.8 ± 5.5	11.6 ± 8.7	T 0.018
						R 0.632
						R × T 0.932
Peak Insulin, μU/ml	124 ± 58	91 ± 37	86 ± 47	81 ± 51	128 ± 143	T 0.981
						R 0.797
						R × T 0.233
GLP-1 AUC, pg•l−1•min−1	9.2 ± 8.4	11.2 ± 7.5	14.8 ± 13.7	12.2 ± 5.5	15.5 ± 11.1	T 0.006
						R 0.911
						R × T 0.840
Peak GLP-1, pg/ml	45 ± 37	69 ± 33	94 ± 74	85 ± 33	132 ± 91	T < .0001
						R 0.785
						R × T 0.249
GIP AUC, pg•l−1•min−1	29.0 ± 11.9	35.5 ± 12.1	33.4 ± 17.6	23.5 ± 8.6	24.4 ± 8.8	T 0.819
						R 0.060
						R × T 0.236
Peak GIP, pg/ml	227 ± 115	246 ± 83	258 ± 134	193 ± 111	242 ± 131	T 0.231
						R 0.416
						R × T 0.895
AG AUC, pg•l−1•min−1	19.5 ± 9.0	14.4 ± 7.6	9.7 ± 4.6	12.0 ± 6.8	11.1 ± 6.2	T 0.001
						R 0.645
						R × T 0.571
Peak AG, pg/ml	100.1 ± 47.3	85.0 ± 52.5	51.4 ± 23.7	66.0 ± 32.3	58.9 ± 33.9	T 0.002
						R 0.511
						R × T 0.537
TG AUC, pg•l−1•min−1	145 ± 53.4	102 ± 25.2	117 ± 31.7	112 ± 36.0	123 ± 22.6	T 0.120
						R 0.923
						R × T 0.691
Peak TG, pg/ml	702 ± 283	511 ± 116	567 ± 105	532 ± 152	573 ± 105	T 0.110
						R 0.802
						R × T 0.866

Data are means ± SD for 9 subjects. AUC, area under the curve; AG, acyl ghrelin; TG, total ghrelin; P values are for the effects of time (T) after gastric bypass surgery, route (R) of meal administration (duodenal vs. jejunal), and the interaction between route and time (R × T).