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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: J Neurochem. 2011 Jan 19;116(4):486–498. doi: 10.1111/j.1471-4159.2010.07128.x

Fig. 3.

Fig. 3

CBL-GFRα1 double transgenic mice have an increased behavioral response to amphetamine. (a) Both double transgenic (DT) and non-transgenic littermate (wildtype, WT) controls show a normal increased activity level when initially placed in the chamber (activity levels at Time = 10 and 20 min were significantly greater than levels at Time = 40 min and all subsequent times; p < 0.001 two-way repeated measures ANOVA; p < 0.05, all pairwise multiple comparison post hoc analysis; WT, n = 9; DT, n = 6). There was no genotype effect. (b) Following administration of amphetamine, there is a much greater degree of behavioral activation in the DT group (p = 0.001 for comparison of factor ‘genotype’, ANOVA, n = 8 both groups) (VEH, vehicle; AMPH, amphetamine).