Fig. 2.

Effect of noise on spontaneous spiking and subthreshold voltage oscillations in the model. A: the model without noise spikes perfectly regularly (top). The effect of the additional white noise current introduces variability in spike timing that simulates variability of spontaneous spiking seen in vitro even in the presence of synaptic blockers (bottom). B: there is a good match in the amplitude of the subthreshold voltage fluctuations between a recorded neuron (top) and the simulation (bottom), further validating our noise model. C: the power spectra of the membrane potential also show a good match between recordings and simulations with noise. Spikes were removed before analysis (see methods). The shaded area indicates the 95% confidence level for the power spectral estimate.