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. 2011 Feb 23;105(5):2108–2120. doi: 10.1152/jn.01037.2010

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Fig. 1. — Group I metabotropic glutamate receptor (mGluR)-mediated modulation of locomotor-related motoneuron output. A: raw (top) and rectified and integrated (bottom) traces showing the effects of the group I mGluR agonist (S)-3,5-dihydroxyphenylglycine (DHPG; 5 μM) on pharmacologically induced (5 μM NMDA, 10 μM 5-HT, and 50 μM dopamine) locomotor activity recorded from the lumbar ventral roots of an isolated mouse spinal cord preparation. B: time-course plots showing a decrease in locomotor burst amplitude (i) and an increase in burst frequency (ii) in response to DHPG application (5 μM, 15 min; n = 11). Each point represents 1 min worth of recording, normalized to control. C: pooled data, averaged from 5 min worth of recording in each condition, showing a significant decrease in locomotor burst amplitude (i) and increase in burst frequency (ii) following the application of DHPG (n = 11). *Significantly different from control.