Table 3.
Effects of potassium channel blockers on properties of RB and DL neurons
| RB |
DL |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Control | TEA | 4-AP | Catechol | MGX | Control | TEA | 4-AP | Catechol | MGX | |
| n | 36 | 13 | 16 | 10 | 14 | 28 | 7 | 13 | 8 | 14 |
| IR, MΩ | 348.3 | 330.7 | 309.9 | 343.6 | 324.7 | 1582.9 | 1303.3 | 1578.3 | 1454.3 | 1786.3 |
| RMP, mV | −70.2 | −73.8 | −70.7 | −68.3 | −69.4 | −58.1 | −56.3 | −53.1 | −56.8 | −54.7 |
| Number of APs | 1.0 | 4.0† | 1.0 | 1.0 | 1.0 | 6.5 | 4.5* | 3.0† | 3.5* | 1.0 |
| Rheobase current, pA | 229.3 | 270.6 | 228.7 | 283.8 | 165.0 | 112.9 | 82.0 | 73.1* | 67.1* | 165.0 |
| AP threshold, mV | −20.8 | −15.4 | −31.7† | −27.8 | −32.8† | −25.5 | −26.1 | −37.4† | −34.2* | −32.8† |
| AP peak, mV | 44.8 | 51.7 | 45.1 | 40.3 | 46.9 | 45.9 | 68.5 | 45.4 | 41.3 | 46.9 |
| AP duration, ms | 1.2 | 3.6* | 1.8 | 1.1 | 1.9* | 0.9 | 2.0 | 1.7 | 1.0 | 1.9* |
| Maximum rate of depolarization, mV/ms | 140.8 | 118.4 | 147.7 | 163.1 | 156.3 | 156.5 | 135.6 | 137.4 | 141.6 | 156.3 |
| Maximum rate of repolarization, mV/ms | 53.1 | 23.8† | 52.4 | 65.0 | 51.5 | 80.1 | 57.1 | 45.7† | 40.3† | 51.5 |
| AHP peak, mV | −47.6 | −29.7† | −55.5 | −52.4 | −54.2 | −50.3 | −19.6* | −46.1 | −42.5 | −54.2 |
Mean values in control conditions and in the presence of drugs are compared for each parameter, with the exception of AP number, where the median value is reported. IR and RMP were used to classify neurons and were unaltered by the drugs used.
*
P value between 0.0001 and 0.05;
†
P value <0.0001.