Fig. 7.
Injury does not alter synaptic NMDAR function. A: average mEPSC waveform recorded from an individual control neuron, in 0.05 MgCl2, in the presence (black trace) and absence (gray trace) of APV. B: APV-sensitive difference current, calculated as the average mEPSC-no APV minus average mEPSC + APV. C: mean APV-sensitive mEPSC currents did not differ for control and injured neurons either in 2 mM MgCl2 (control, n = 22; immediate, n = 10; 4 h, n = 11; 2 days, n = 10, P > 0.05) or 0.05 mM MgCl2 (control, n = 15; immediate, n = 8; 4 h, n = 7; 2 days, n = 6). D: APV-sensitive difference in mEPSC charge transfer did not differ significantly for injured neurons vs. control in either 2 mM MgCl2 or 0.05 mM MgCl2.