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. 2011 Mar 2;105(5):2405–2420. doi: 10.1152/jn.01088.2010

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Fig. 5. — Response properties of SON neurons to acoustic stimulation are modulated by GABAergic inhibitory inputs. A: example of SON responses during local iontophoresis of bicuculline during acoustic stimulation. PST histograms are shown for the control, bicuculline, and recovery conditions. Number of spikes increases in the presence of bicuculline, particularly during suprathreshold stimulation and then recovers when iontophoresis of the drug is turned off. Black bar represents the 50-ms stimulus tone. Spike counts are the total for entire PST histogram shown. Bi: rate-level functions for control (Con), bicuculline, and recovery (Rec) conditions from the same cell as in A. Bii: summary population data for GABA_A receptor block. GABA_A block significantly increases the peak spike rate (re: the peak control rate; *P < 0.05). GABA_A block also significantly increases the slope of the dynamic range (calculated over the intensity range derived from 10–90% of threshold to maximum rate in control; *P < 0.01).