Table 1.
Raw data values for evoked, spontaneous, and miniature IPSCs during in vitro whole cell voltage clamp experiments
| Condition | Peak Amplitude, pA | Area, pA | Halfwidth, ms | τrise, ms | τdecay, ms | Frequency, Hz |
|---|---|---|---|---|---|---|
| Evoked IPSCs | ||||||
| Control (n = 20) | −947 ± 957 | −4339 ± 3557 | 3.92 ± 2.29 | 1.56 ± 0.83 | 4.41 ± 2.93 | – |
| Strychnine (n = 12) | −510 ± 611 | −2807 ± 2513 | 5.45 ± 3.26 | 1.70 ± 0.85 | 7.03 ± 3.55 | – |
| SR95531 (n = 14) | −310 ± 216 | −741 ± 353 | 2.35 ± 1.03 | 1.23 ± 0.77 | 2.34 ± 0.88 | – |
| SN + SR (n = 13) | −35.6 ± 48.0 | −135 ± 108 | – | – | – | – |
| Recovery (n = 15) | −676 ± 672 | −3227 ± 2584 | 3.83 ± 2.25 | 1.53 ± 0.58 | 5.35 ± 3.82 | – |
| Spontaneous IPSCs | ||||||
| Control (n = 18) | −114 ± 48.2 | −428 ± 192 | 1.93 ± 0.61 | 0.91 ± 0.22 | 4.35 ± 1.61 | 7.45 ± 6.51 |
| Strychnine (n = 12) | −73.3 ± 35.6 | −329 ± 147 | 2.32 ± 1.10 | 0.99 ± 0.31 | 6.48 ± 4.41 | 8.49 ± 4.58 |
| SR95531 (n = 16) | −95.3 ± 53.6 | −278 ± 169 | 1.39 ± 0.43 | 0.84 ± 0.37 | 2.91 ± 1.69 | 1.87 ± 1.38 |
| Recovery (n = 14) | −103 ± 61.5 | −398 ± 209 | 2.09 ± 1.00 | 1.06 ± 0.55 | 5.59 ± 4.10 | 7.76 ± 6.75 |
| Miniature IPSCs | ||||||
| Control (n = 6) | −141 ± 48.7 | −496 ± 112 | 2.26 ± 0.48 | 0.90 ± 0.33 | 4.71 ± 1.26 | 11.3 ± 7.02 |
| Strychnine (n = 5) | −63.1 ± 17.2 | −244 ± 60.4 | 2.11 ± 0.44 | 1.06 ± 0.32 | 7.46 ± 1.12 | 9.11 ± 6.61 |
| SR95531 (n = 5) | −92.2 ± 41.2 | −308 ± 113 | 1.81 ± 0.26 | 0.87 ± 0.24 | 4.34 ± 1.01 | 1.81 ± 0.98 |
| Recovery (n = 5) | −122 ± 84.6 | −436 ± 255 | 2.20 ± 0.39 | 0.97 ± 0.20 | 5.09 ± 1.08 | 10.8 ± 6.51 |
Values indicate mean ± SD. IPSCs, inhibitory postsynaptic currents; SN, strychnine, SR, SR95531.