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. 2011 Mar 9;105(5):2043–2049. doi: 10.1152/jn.00852.2010

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Fig. 1. — Changes in weight-bearing forces of the rat hindlimb after ankle sprain and the effect of morphine treatment. A and B: examples of weight-bearing force traces of the forelimb (F) and hindlimb (H) in a normal rat (A) and a rat 1 day after ankle sprain (B). As shown in C, the stepping force of the hindlimb is ∼64% of total body weight in normal locomotion (N). One day after ankle sprain (Sp), the weight-bearing ratio decreased to 27%. Morphine treatments [1 hr after 2 (M2) and 5 mg/kg ip (M5) of morphine] induced a recovery of the weight-bearing forces in a dose-dependent manner. Saline treatment (S) had no effect. The value of the ordinate was expressed as the percent ratio of the stepping force to body weight. Values are means ± SE; n = 10 rats in the normal group, 8 rats in the Sp group, 8 rats in the Sp + S group, 8 rats in the Sp + M2 group, and 8 rats in the Sp + M5 group. Abscissa indicate animal groups. *Value was significantly different (P < 0.05) from the normal condition; #value was significantly different (P < 0.05) from Sp condition.