Figure 4.

Monocyte genes specifically induced by 15 kDa Granulysin. Hierarchical clustering of the 152, 498, 429 and 598 genes induced by 15 kDa Granulysin at 4 (a), 12 (b), 24 (c) and 48 (d) hours respectively (p-value < 0.001, FDR < 0.1) and the relative GO analysis. The expression of each of these genes differed in Granulysin treated monocytes compared to both time 0 monocytes and cells treated with GM-CSF at the same time points. The hierarchical cluster analysis were T0 corrected, the black bar indicates T0 monocytes, the fuchsia bar GM-CSF-treated monocytes, and the light blue bar Granulysin-treated monocytes. GO analyses were made with DAVID. The bars in the GO analysis indicate -Log10 of the p-value of the overrepresentation of the induced genes for each GO family. The green bars indicate down-regulated genes, while red ones indicate up-regulated genes. The orange line indicates the threshold of statistical significance (p-value = 0.05)