Table 1.
Predominant functional annotations obtained for genes found in selected clusters from Figure 2
| Cluster1 | Functional categories2 | TF3 | Selection of genes |
|---|---|---|---|
| II | Carbohydrate metabolism Energy reserve metabolic processes Oxidative phosphorilation Utilization of amino acids as N source Glutamate pool management Amino acid transport |
STRE element Msn2p Msn4p Adr1p Sut1p |
DAL2-4, DAL82, DUR1,2, PUT2, GDH2, GDH3, GAP1, UGA4 |
| V | Generation of precursor metabolites and energy Trans-membrane transport Pleiotropic drug resistance Amino acid biosynthesis and transport |
Adr1p | SNF1, JEN1, CAT8, ADR1, MAL31, HXT5, AZR1, PDR10, YOR1, CRS5, TPO2, TPO3, MUP3, STR3, MET32, PUT4 |
| X | Sugar transport Pheromone signaling Mating Meiotic recombination |
No enrichment | MAL11, MPH2, BAR1, STE2, STE6, PRM8, ASG7, FUS1, GPA1, MFA2, STE18, HO, REC102, SPO11 |
| XII | Response to toxins Nitrogen catabolite repression |
No enrichment | AAD4, AAD6, AAD14, AAD16, ADH7, DAL80 |
| XIII | Sterol metabolism Thiamine biosynthesis Cell wall composition Iron homeostasis Pleiotropic drug resistance |
Mot3p Nrg1p Aft2p Cin5p |
DAN1-DAN4, TIR4, PAU1-PAU6, ARE1, HES1, FET4, PDR11 |
1Clusters highlighted in Figure 2A; 2Derived from GO term enrichment analysis (p-value < 0.05); 3Obtained from enrichment analysis for transcription factor binding site in the gene promoter region (p-value < 0.05, adjusted with Bonferroni multiple tests correction).