Table 3.

Summary of main results on published studies on the conformal radiotherapy and FSRT of skull base meningiomas

authors	Patients (n)	Technique (%)	Volume (ml)	Dose (Gy)	Follow-up (months)	Local control (%)	Late toxicity (%)
Goldsmith et al., 1994	117	CRT	NA	54	40	89 at 5 and 77 at 10 years	3.6
Maire et al., 1995	91	CRT	NA	52	40	94	6.5
Peele et al., 1996	42	CRT	NA	55	48	100	5
Condra et al.,1997	28	CRT	NA	53.3	98	87 at 15 years	24
Connell et al., 1999	54	CRT	NA	54	55	76 at 5 years	19
Maguire et al., 1999	26	CRT	NA	53	41	8 at 8 years	8
Nutting et al., 1999	82	CRT	NA	55-60	41	92 at 5 and 83 at 10 years	14
Vendrely et al., 1999	156	CRT	NA	50	40	79 at 5 years	11.5
Dufour et al., 2001	31	CRT	NA	52	73	93 at 5 and 10 years	3.2
Pourel et al., 2001	28	CRT	NA	56	30	95 at 5 years	4
Mendenhall et al., 2003	101	CRT	NA	54	64	95 at 5, 92 at 10 and 15 years	8
Debus et al., 2001	189	FSRT	52.5	56.8	35	97.3	1.6
Jalali et al., 2002	41*	FSRT	17.9	55	21	100	12.1
Lo et al., 2002	18*	FSRT	8.8	54	30.5	93.3	5
Torres et al., 2003	77*	FSRT	16.1	48.4	24	97.2	5.2
Selch et al., 2004	45	FSRT	14.5	56	36	100 at 3 years	0
Milker-Zabel et al., 2005	317*	FSRT	33.6	57.6	67	90.5 at 5 and 89 at 10 years	8.2
Henzel et al., 2006	84	FSRT	11.1	56	30	100	NA
Brell et al., 2006	30	FSRT	11.3	52	50	93 at 4 years	6.6
Hamm et al., 2008	183	FSRT	27.4	56	36	97 at 5 years	8.2
Litré et al., 2009	100	FSRT	NA	45	33	94 at 3 years	0
Metellus et al., 2010	47	FSRT	12.6	52.9	82.8	98 at 5 and 96 at 10 years	2.6
Tanzler E et al., 2010	144**	FSRT	NA	52.7	96	97 at 5 and 96 at 10 years	7

CRT, conformal 3-D radiotherapy; FSRT, fractionated stereotactic radiotherapy

*Series include some patients with intracranial meningiomas

** 41 patients received CRT