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. 2011 May 13;6(5):e19939. doi: 10.1371/journal.pone.0019939

Figure 1. SaeR/S promotes bacterial persistence and host mortality in a mouse model of S. aureus peritonitis.

Figure 1

Mice were inoculated i.p. with MW2 or MW2ΔsaeR/S (5×107 cfu) for (A) 4 hours and (B–E) 10 hours. (A) S. aureus burden in the peritoneal exudate, NS. For data in (A), results are from 3 biological replicates of 5 mice/group (n = 15). (B) S. aureus burden in peritoneal exudate, ****P<0.0001. (C) S. aureus burden in the kidneys, ****P<0.0001. (D) S. aureus burden in the heart, **P<0.01. E, S. aureus burden in the blood, NS. For data in (B–E), results are from 2 biological replicates of 7 and 8 mice/group (n = 15). All tissues compared were individually analyzed by t test. (F) Survival curve for mice inoculated (i.p.) with 5×107 cfu of MW2 or MW2ΔsaeR/S, *P<0.001 as determined by logrank test (n = 10/group). Mice receiving PBS had no S. aureus cfu (data not shown). NS = not significant.