Figure 2. SaeR/S elicits systemic pro-inflammatory cytokines during invasive S. aureus infection.
Mice were inoculated i.p. with MW2, MW2ΔsaeR/S (5×107 cfu) or PBS for 10 hours and serum cytokine concentrations were measured by cytometric bead array. Serum concentrations (pg/ml) of (A) IFN-γ, (B) TNF, (C) IL-6, (D) IL-2, (E) IL-17A, (F) IL-10 and (G) IL-4. Results displayed are from 5 mice (MW2), 7 mice (MW2ΔsaeR/S) and 2 mice (PBS). *P<0.05 and **P<0.01 compared to cytokine expression in MW2-infected mice for each cytokine investigated as determined by t test. NS = not significant; N/D = not detectable.