Table 1.
Blood leukocytes counts, LTL, hTERT mRNA expression, and hTERT promoter methylation measured in 63 foundry workers at baseline and postexposure.
| Baseline
|
Postexposure
|
|||||
|---|---|---|---|---|---|---|
| Outcome | na | Mean ± SD | Range | Mean ± SD | Range | p-Value |
| White blood cells (103/mm3) | 62 | 7.31 ± 1.6 | 3.6–10.4 | 7.3 ± 1.7 | 4.0–13.0 | 0.91 |
| Granulocytes (%) | 62 | 58.9 ± 7.2 | 43.5–76.0 | 58.2 ± 7.6 | 44.6–80.6 | 0.23 |
| Lymphocytes (%) | 62 | 30.7 ± 6.7 | 15.4–44.1 | 32.0 ± 7.3 | 15.7–47.0 | 0.069 |
| Monocytes (%) | 62 | 10.4 ± 3.5 | 4.5–19.4 | 9.8 ± 3.5 | 3.7–17.5 | 0.22 |
| LTL (T/S ratio) | 57 | 1.23 ± 0.28 | 0.68–1.86 | 1.43 ± 0.51 | 0.72–3.34 | < 0.001 |
| hTERT expression (2−ΔΔCT) | 58 | 1.68 ± 0.86 | 0.72–4.86 | 1.31 ± 0.75 | 0.52–5.55 | < 0.001 |
| hTERT methylation (% 5mC) | ||||||
| Position 1 | 59 | 93.9 ± 1.0 | 90.5–96.8 | 93.9 ± 1.1 | 89.9–96.8 | 0.84 |
| Position 2 | 59 | 93.8 ± 2.8 | 80.4–100.0 | 93.6 ± 3.1 | 79.2–97.1 | 0.67 |
| Position 3 | 59 | 90.0 ± 1.9 | 86.3–95.5 | 90.2 ± 1.5 | 85.9–93.2 | 0.36 |
a
The numbers of observations vary because of missing values due to failed laboratory analyses.