Table 2.

Relative risks of death for carriers of different APOE genotypes.

Models*	Allele	Genotypes
	e4, any	e2/4	e3/4	e4/4	overall p-value
M0	1.25 (0.018)	1.38 (0.270)	1.17 (0.127)	2.26 (9.7×10−4)	4.2×10−3
M1	1.21 (0.040)	1.31 (0.357)	1.13 (0.225)	2.30 (7.5×10−4)	5.2×10−3
M2	1.34 (1.9×10−3)	1.27 (0.408)	1.26 (0.023)	2.70 (6.6×10−5)	1.8×10−4
M3	1.34 (1.9×10−3)	1.28 (0.405)	1.26 (0.023)	2.68 (7.0×10−5)	1.9×10−4
M4	1.35 (1.3×10−3)	1.32 (0.350)	1.27 (0.019)	2.71 (6.1×10−5)	1.4×10−4

M0: no adjustments; M1: adjustments by age and sex; M2: M1 + prevalence of CVD and cancer; M3: M2 + Relatedness; M4: M3 + body mass index (kg/m²), smoking, and drinking.

Numbers show relative risks (p-values) for carriers of the risk allele (e4, any) and for carriers of each genotype with the e4 allele (“Genotypes”). Column “overall p-value” shows significance of the overall model in the latter case, i.e., this is the result of the test of the null hypothesis that all the effect coefficients for this categorical variable are zero. The non-e4-allele carriers were the reference group.

^*Sample size is given in Figure 1.