Table 3.
Relative risks of onsets of CVD and cancer for carriers of different APOE genotypes.
| Trait | Model | Allele | Genotypes | |||
|---|---|---|---|---|---|---|
| e4, any | e2/4 | e3/4 | e4/4 | overall p-value |
||
| CVD | M0* | 1.24 (0.007) | 0.99 (0.968) | 1.26 (0.006) | 1.29 (0.310) | 0.040 |
| M1** | 1.14 (0.113) | 1.04 (0.892) | 1.17 (0.068) | 0.90 (0.692) | 0.306 | |
| M1**+cancer | 1.13 (0.127) | 1.04 (0.883) | 1.16 (0.078) | 0.90 (0.682) | 0.334 | |
| M2**+cancer | 1.14 (0.099) | 1.05 (0.851) | 1.17 (0.060) | 0.90 (0.686) | 0.277 | |
| M3**+cancer | 1.14 (0.112) | 0.98 (0.994) | 1.17 (0.057) | 0.88 (0.629) | 0.258 | |
| Cancer | M0* | 0.86 (0.116) | 1.38 (0.205) | 0.80 (0.032) | 1.08 (0.788) | 0.080 |
| M1**+CVD | 0.84 (0.080) | 1.38 (0.208) | 0.78 (0.019) | 1.08 (0.800) | 0.054 | |
| M2**+CVD | 0.84 (0.071) | 1.36 (0.228) | 0.78 (0.017) | 1.07 (0.815) | 0.052 | |
| M3**+CVD | 0.84 (0.065) | 1.33 (0.266) | 0.77 (0.016) | 1.06 (0.854) | 0.058 | |
M0: no adjustments; M1: adjustments by age, sex, relatedness, total cholesterol (mg/1000 ml), and high density lipoprotein cholesterol (mg/1000 ml); M2: M1 + body mass index (kg/m2); M3: M2 + smoking and drinking. Cholesterol levels were divided by 10 for better visibility.
Numbers show relative risks (p-values) for carriers of the risk allele (e4, any) and for carriers of each genotype with the e4 allele (“Genotypes”). Column “overall p-value” shows significance of the overall model in the latter case. The non-e4-allele carriers were the reference group.
Sample size is given in Figure 2.
Sample sizes are slightly smaller due to about 2% of missing values for the total and high density lipoprotein cholesterol measurements.