Table 1.
Physical characteristics of the ambroxol hydrochloride loaded microspheres
| Formulation code | Drug: polymer ratio | % Yield | Entrapment efficiency | Mean particle size (µm) | SPAN |
|---|---|---|---|---|---|
| FA1 | 1:1 | 85.98 | 68.45 ± 0.745 | 10.83 ± 0.035 | 2.146 |
| FA2 | 1:2 | 91.45 | 76.20 ± 0.234 | 13.81 ± 0.124 | 2.854 |
| FA3 | 1:3 | 89.26 | 78.57 ± 1.024 | 16.95 ± 0.078 | 1.934 |
| FA4 | 1:4 | 79.44 | 80.56 ± 0.928 | 17.91 ± 0.382 | 2.301 |
| H1 | 1:1 | 95.34 | 39.73 ± 0.640 | 18.02 ± 0.463 | 2.289 |
| H2 | 1:2 | 92.68 | 40.98 ± 1.245 | 20.82 ± 1.082 | 2.147 |
| H3 | 1:3 | 88.25 | 45.23 ± 0.735 | 22.27 ± 0.846 | 2.032 |
| H4 | 1:4 | 80.56 | 58.65 ± 0.862 | 24.11 ± 0.628 | 1.778 |