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. 2011 Apr 20;31(16):6159–6173. doi: 10.1523/JNEUROSCI.0577-11.2011

Figure 3.

Figure 3.

Environmental enrichment before social defeat exposure prevents a stress-induced decrease of FosB/ΔFosB expression in brain areas associated with positively motivated behaviors. In non-defeat exposed home-cage mice, EE significantly enhanced FosB/ΔFosB expression in the prelimbic (a), infralimbic (b), piriform (c), and anterior cingulate (d) cortices, nucleus accumbens (e), and intercalated cell islands of the amygdala (f). Within these brain regions, EE before SD prevents a stress-induced decline of FosB/ΔFosB expression observed in defeated mice previously housed in SE or IE. SD stress significantly increased FosB/ΔFosB in the paraventricular nucleus of impoverished and standard housed mice (g). Results are expressed as mean ± SEM (n = 7 per group) Two-way ANOVA followed by Bonferroni's post hoc test. Bonferroni's test: *p < 0.05; **p < 0.01; ***p < 0.001.