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. 2011 Apr 20;31(16):6159–6173. doi: 10.1523/JNEUROSCI.0577-11.2011

Figure 6.

Figure 6.

Lesions of the IL cortex before (ILinf→EE→SD), but not after (EE→ILinf→SD), EE housing alter the pattern of FosB/ΔFosB expression in response to chronic social defeat stress. Animals receiving lesions before or after EE housing showed a significant reduction in FosB/ΔFosB immunostaining within the PL (a) compared with non-defeat lesioned control mice (ILinf→EE). In the IL (b), FosB/ΔFosB immunostaining was significantly reduced in all groups receiving ibotenate lesions. Lesions had no effect on FosB/ΔFosB immunostaining in the PIR (c). In the CG (d), Acb (e), ITC (f), and PVN (g), animals receiving lesions before EE showed markedly significant decreases in FosB/ΔFosB immunostaining after SD, whereas animals receiving lesions after EE showed no significant change in FosB/ΔFosB immunostaining after SD compared with sham-lesioned groups and non-defeated control groups. FosB/ΔFosB immunostaining in the PVN was significantly enhanced after SD in mice that received IL lesions before EE; no change was observed in animals that received lesions after EE. Results are expressed as mean ± SEM (n = 6 per group). Two-way ANOVA followed by Bonferroni's post hoc test. Bonferroni's test: *p < 0.05; ***p < 0.001.