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A schematic shows extracellular and intracellular MMP-2 in muscle atrophy. Normal transcription of MMP-2 generates extracellular MMP-2 with a signal peptide, which directs it to the extracellular matrix. An alternative transcription mechanism generates an intracellular form of MMP-2 without the signal peptide. The intracellular MMP-2 remains inside the muscle cell and results in intracellular matrix degradation of the muscle.
