Table 4.
Outcome in seven studies with follow-up ≥ 4 years
| Publication year (reference) | Dropout rate (%) | Headache days/month baseline | Duration of follow-up (years, mean) | Headache days/month Follow-up | Responder rate1 (%) | Relapse rate (%) | Statistical significant predictors |
|---|---|---|---|---|---|---|---|
| 1996 [13]Ba | 30 | – | 5 | – | 50A | 40 | Number of tablets, duration of drug abuse |
| 1999 [15]Ba | 61 | – | 5.9 | 12.3 | – | 21 | Sex, type of overused drugs |
| 2001 [16]Bd | 12 | – | 4 | – | – | 60 | Number of tablets, duration of drug abuse |
| 2001 [12]Bd | – | – | 9.3 | – | 351 | 33 | None |
| 2004 [14]Ba | 22 | – | 4 | – | – | 45 | Headache type, type of overused drugs |
| 2009 [11]Bb | 45 | 26.1 | 5 | 11.3 | 78 | – | None |
| 2010 [17]Bc | 6 | – | 4 | – | – | 44 | Remission at year 1 |
| Mean | 29 | 26.1 | 5.3 | 11.8 | 54 | 41 |
AHeadache ≤8 days or less without medication overuse
BMOH diagnosis based on: (a) First version of the International Headache Society (IHS) from 1988 (ICDH-1), (b) criteria proposed by Silberstein and Lipton in 2000, (c) ICDH-2 or later versions, or (d) other criteria or not clearly stated