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The effects of naloxone and naloxonazine on EA-induced alterations in sleep. Both naloxone and naloxonazine dose-dependently blocked the EA-induced enhancement of NREM sleep. *Represents a statistically significant difference between the values obtained from ipketamine + naloxone + EA/ipketamine + naloxonazine + EA and ipketamine + PFS + EA. The black horizontal bar on the x-axis represent the dark period of the 12 : 12 h light : dark cycle.
